NFL Wild Card Predictions 2022 – Top Picks for this weekend

Updated: August 21, 2025

Welcome to our expert NFL Wild Card Predictions for 2022.

Las Vegas Raiders @ Cincinnati Bengals

The Las Vegas Raiders just squeaked into the playoffs despite all of this adversity battling them the entire season. They have a new head coach; their top wide receiver is facing prison time and two young cornerbacks have been arrested. It’s been a rough season but Derek Carr is taking this team as far as he can. They have a tough Wild Card date with the Cincinnati Bengals though. Cincinnati hasn’t won a playoff game in over a decade I believe but Joe Burrow could be the quarterback to finally flip that narrative. Him and Ja’Marr Chase have played stellar football all season, and their infectious attitudes seem to have given this team a certain swagger. This is going to be one of the more exciting games of the bunch, but I am going to be rolling with the Bengals here. I have a lot of faith in Burrow and company while the Raiders have seriously been inconsistent.

Pick: Cincinnati Bengals

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New England Patriots @ Buffalo Bills

We already saw these two teams battle it out twice this season. The first matchup came in the freezing cold when the Patriots won by attempting just three passes. Then the second we saw Buffalo dominate the game and pull out a win in their own stadium. This game should be one of the coldest playoff atmospheres of all time, which should make for some interesting football to say the least. Mac Jones will get to prove what he can do on his biggest NFL stage yet while Josh Allen will try and get his team to the Super Bowl. New England seems perfectly designed to beat the Bills right now, but lately they really haven’t looked that good. Plus, we never know exactly how rookie quarterbacks fare in their very first playoff game, I mean just look at what happened with Allen a few years ago. This will certainly be a close game the entire way, but I have more faith in Allen than Jones, which is why I am taking the Bills.

Pick: Buffalo Bills

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Philadelphia Eagles @ Tampa Bay Buccaneers

This is a very unfortunate matchup for the Eagles. This team is definitely overachieving by just making the postseason, though they are hoping to go a little further. Jalen Hurts gets to showcase his skills in the postseason for the first time behind a surprisingly strong run game. However, their defense is really the problem in this scenario. The Tampa Bay Buccaneers are a powerful offense despite not having Chris Godwin or Antonio Brown available. Tom Brady has proven that doubting him will only help him advance further into the playoffs and Mike Evans, Rob Gronkowski and Leonard Fournette aren’t bad weapons to have alongside him. Brady has torn apart this Philadelphia defense in the past, and it doesn’t look like the Eagles have it in them to make it past Tampa Bay. I will be rolling with the Buccaneers in this one even with their injuries. They are a better team and are more experienced by a long shot.

Pick: Tampa Bay Buccaneers

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San Francisco 49ers @ Dallas Cowboys

The 49ers came back from a 17-point deficit and beat the Los Angeles Rams in overtime to secure this playoff spot. They won’t want to just go quietly into the night. Jimmy Garoppolo kind of holds this team back right now, but Deebo Samuel and George Kittle have been so amazing that it hasn’t really mattered much. Elijah Mitchell is also incredibly slept on this season. As for their defense, Fred Warner is about the best linebacker you could ask for. There are playmakers all over the place for San Francisco though, just like Dallas. The Cowboys weren’t a popular team at the beginning of the year but man have they turned it around. Dak Prescott is a wonderful leader and great quarterback. Ezekiel Elliott and Tony Pollard are quite the backfield tandem. Then Amari Cooper and Ceedee Lamb are an excellent wideout duo. This team also has the interception leader Trevon Diggs on their team and the possible Defensive Player of the Year Micah Parsons. I didn’t expect the 49ers to make the playoffs, but here they are. This will be a wildly close game but I have some hope that the Cowboys will walk away with the win. They have been better all season.

Pick: Dallas Cowboys

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Pittsburgh Steelers @ Kansas City Chiefs

Everybody should know by now that it isn’t ever a good idea for fans to severely doubt a playoff team. Yes, the Pittsburgh Steelers shouldn’t have made the playoffs but at the end of the day they did. Ben Roethlisberger has already succeeded in the postseason in the past, and considering how badly they are being overlooked he could surprise some people. This defense is really good and Juju Smith-Schuster is primed to make a return for the first time since about Week 4. The Chiefs are probably the only team in the league that should be able to overlook this noise in the background. Patrick Mahomes, Tyreek Hill and Travis Kelce are still probably the top trio in the league offensively. Their defense has also stepped up dramatically towards the back end of the year. I am picking the Chiefs in this one but it won’t be a blowout like their previous game was earlier this season.

Pick: Kansas City Chiefs

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Arizona Cardinals @ Los Angeles Rams

Both of these teams admittedly don’t look that good heading into the Wild Card Round. Arizona is collapsing for the second straight year at this point in the season. Kyler Murray is playing great and James Connor is stellar, but something just isn’t clicking right now for them. As for the Rams, Matthew Stafford has turned the ball over quite a few times the last few weeks. Causing their last couple of games to go down to the wire when they should have easily blown the doors off them. Despite the tremendous amount of talent split across these two rosters, I can’t say that I fully trust either of them. I am going to go with an upset here and take the Cardinals, maybe they can avenge their poor play.

Pick: Arizona Cardinals

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NFL Wildcard Props

The best NFL Wildcard Props from the BetOnline sportsbook.

Team Props

Total Wild Card teams to win

Over 2 Under 2

Will a Wild Card team make Super Bowl

Yes +250 No -400

Will a Wild Card team win Super Bowl

Yes +550 No -1000

Player Props

Passing yards leader

Tom Brady +500 Joe Burrow +575 Matthew Stafford +575 Derek Carr +600 Dak Prescott +625 Patrick Mahomes +625 Kyler Murray +850 Jimmy Garoppolo +900 Josh Allen +1000 Ben Roethlisberger +1200 Mac Jones +1800 Jalen Hurts +2000

Receiving yards leader

Cooper Kupp +350 Ja'Marr Chase +700 Stefon Diggs +800 Deebo Samuel +850 Mike Evans +900 Travis Kelce +1100 Tyreek Hill +1100 Amari Cooper +1400 CeeDee Lamb +1400 Rob Gronkowski +1400 Diontae Johnson +1600 Tee Higgins +1600 Christian Kirk +1800 Darren Waller +2000 DeVonta Smith +2000 Hunter Renfrow +2000 Brandon Aiyuk +2200 George Kittle +2200 Breshad Perriman +2800 Chase Claypool +3300 Mecole Hardman +3300 Tyler Boyd +3300 Zach Ertz +3300 Zay Jones +3300 Cedrick Wilson +4000 A.J. Green +5000 Byron Pringle +5000 Cole Beasley +5000 Emmanuel Sanders +5000 Jakobi Meyers +5000 Odell Beckham +5000 Van Jefferson +5000 Bryan Edwards +6600 Kendrick Bourne +6600 Quez Watkins +6600 Tyler Johnson +6600 Nelson Agholor +10000 Rondale Moore +10000

Rushing yards leader

Joe Mixon +600 Elijah Mitchell +700 Josh Jacobs +700 Leonard Fournette +750 Najee Harris +750 Devin Singletary +800 Ezekiel Elliott +800 Sony Michel +900 Damien Harris +1200 Miles Sanders +1200 Clyde Edwards-Helaire+1600 Jalen Hurts +2000 James Conner +2000 Josh Allen +2000 Kyler Murray +2200 Darrel Williams +2800 Tony Pollard +2800 Deebo Samuel +3300 Rhamondre Stevenson+3300 Ronald Jones +3300 Cam Akers +4000 Chase Edmonds +4000

Will Matthew Stafford throw a pick six?

Yes No

Will Joe Burrow throw for 400+ yards?

Yes +350 No -600

Will TJ Watt have a sack?

Yes -175 No +135

Will Aaron Donald have a sack?

Yes -175 No +135

Will Trevon Diggs have an interception?

Yes +250 No -400

Will Trey Lance take a snap?

Yes +150 No -200

Will any non-QB throw a pass?

Yes +200 No -300

Game Props

Highest scoring game

SF 49ers @ DAL Cowboys +325 ARI Cardinals @ LA Rams +350 LA Raiders @ CIN Bengals +400 PHI Eagles @ TB Buccaneers +400 PIT Steelers @ KC Chiefs +650 NE Patriots @ BUF Bills +750

Lowest scoring game

NE Patriots @ BUF Bills +225 PIT Steelers @ KC Chiefs +375 LA Raiders @ CIN Bengals +550 PHI Eagles @ TB Buccaneers +550 ARI Cardinals @ LA Rams +600 SF 49ers @ DAL Cowboys +650

Highest scoring team

KC Chiefs +350 TB Buccaneers +400 CIN Bengals +550 LA Rams +550 DAL Cowboys +750 SF 49ers +900 BUF Bills +1200 ARI Cardinals +1400 LV Raiders +2000 NE Patriots +2200 PHI Eagles +2200 PIT Steelers +3300

Lowest scoring team

PIT Steelers +265 NE Patriots +450 PHI Eagles +500 LV Raiders +600 ARI Cardinals +800 BUF Bills +1000 SF 49ers +1200 DAL Cowboys +1600 CIN Bengals +2000 LA Rams +2200 KC Chiefs +3300 TB Buccaneers +3300

Most points scored by any team

Over 40.5 Under 40.5

Total points scored

Over 287.5 Under 287.5

Home Team vs. Away Team point differential

Away +37.5 Home -37.5

Largest point differential in any game

Over 20.5 Under 20.5

Will any team get shut out?

Yes +1000 No -5000

Will any game go to overtime?

Yes +250 No -400

Will there be a walkoff win?

Yes +100 No -140

Will any team score a defensive/special teams TD?

Yes -800 No +450

Prop Bets at BetOnline