NFL Experts Mike Florio and Chris Simms Head-to-Head in Intense Week 4 Predictions Showdown

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Updated: October 15, 2025

Week 4 of the 2025 NFL season brought an exciting clash between experts Mike Florio and Chris Simms as they put their predictive skills to the test. As the season progressed, the competition between the two tightened, with Simms taking the lead in Week 3 microcontest, going 12-4 against Florio's 10-6. With a record of 36-12 for Florio and 29-19 for Simms for the season, the stakes were high as they only disagreed on one game for Week 4.

Seattle Seahawks at Arizona Cardinals

Both teams, the Seahawks and the Cardinals, have exceeded expectations thus far. While the Seahawks have shown a slight edge over the Cardinals, the game promised to be a closely contested one. Florio predicted a Seahawks victory with a score of 23-20, while Simms forecasted a similar outcome with the Seahawks winning 24-20.

Minnesota Vikings vs. Pittsburgh Steelers at Dublin

In their matchup, the Steelers had followed a simple formula – being outplayed generally but not outscored. Florio foresaw a Steelers win at 24-21, while Simms predicted a narrower victory for the Steelers at 23-20 over the Vikings.

Washington Commanders at Atlanta Falcons

Heading into the game, there was speculation about former Falcons head coach Dan Quinn's thoughts as the Commanders faced the Falcons. Florio picked the Commanders to win decisively with a score of 30-17, while Simms also chose the Commanders but with a predicted score of 24-17.

New Orleans Saints at Buffalo Bills

The Bills, with a significant spread of 15.5 points, were seen as the favorites against the Saints. Florio estimated a 10-point victory for the Bills at 24-14, whereas Simms was more optimistic, predicting the Bills to win 34-17 over the Saints.

Cleveland Browns at Detroit Lions

The struggling Lions faced off against the Browns, whose offensive capabilities were questioned. Florio picked the Lions to dominate with a score of 35-6, while Simms also favored the Lions but with a prediction of 28-13 against the Browns.

Tennessee Titans at Houston Texans

Both the Titans and the Texans were grappling with internal issues, with the Titans showing signs of more dysfunction. Florio anticipated a low-scoring win for the Texans at 13-3, while Simms predicted a 24-10 victory for the Texans over the Titans.

Carolina Panthers at New England Patriots

For the Panthers-Patriots matchup, a critical game for the Patriots, Florio predicted a 24-13 win for New England, emphasizing the importance of a victory for their playoff hopes. Simms echoed the sentiment, picking the Patriots to win 27-17 against the Panthers.

Los Angeles Chargers at New York Giants

The Chargers under Jim Harbaugh were on a roll as they faced the Giants. Florio forecasted a 27-17 victory for the Chargers, while Simms predicted a higher-scoring game with a 31-16 win for Los Angeles over the Giants.

Philadelphia Eagles at Tampa Bay Buccaneers

The Eagles sought to break the trend of recent losses to the Buccaneers, promising an intense matchup. Florio chose the Eagles to win 27-23 over the Buccaneers, while Simms anticipated a 31-21 victory for Philadelphia against Tampa Bay.

Indianapolis Colts at Los Angeles Rams

Following a heartbreaker last week, the Rams aimed to bounce back against the Colts. Florio predicted a 27-17 win for the Rams, while Simms envisioned a closer game with a 28-24 victory for Los Angeles over Indianapolis.

Jacksonville Jaguars at San Francisco 49ers

The 49ers, dealing with injuries, faced the Jaguars who had a history of giving games away. Florio foresaw a narrow 20-19 victory for the 49ers, while Simms went against the tide and predicted a 21-17 win for the Jaguars over the 49ers.

Baltimore Ravens at Kansas City Chiefs

The Ravens aimed to secure a significant win against the Chiefs to maintain their momentum. Florio predicted a 27-23 win for the Ravens over the Chiefs, while Simms anticipated a more decisive victory for Baltimore at 30-21 against Kansas City.

Chicago Bears at Las Vegas Raiders

With a new approach under Ben Johnson, the Bears prepared to face the Raiders with optimism. Florio picked the Bears to win 30-27 against the Raiders, while Simms forecasted a 31-24 victory for Chicago over Las Vegas.

Green Bay Packers at Dallas Cowboys

In a matchup with the Cowboys, the Packers aimed to secure a victory. Florio predicted a 34-20 win for the Packers over the Cowboys, while Simms anticipated a 31-21 victory for Green Bay against Dallas.

New York Jets at Miami Dolphins

The Dolphins sought to maintain their momentum against the Jets, understanding the implications of a loss. Florio favored the Dolphins to win 24-16, while Simms predicted a closer game with a 23-20 victory for Miami over New York.

Cincinnati Bengals at Denver Broncos

In their matchup, the Broncos, striving to avoid a 1-3 record, took on the Bengals. Florio predicted a 28-10 win for the Broncos over the Bengals, while Simms anticipated a 34-17 victory for Denver against Cincinnati.
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